Calorie Restriction with Optimum Nutrition
NEWS! Aubrey de Grey in Popular Science article [see What's New] | Most-Current Theories of Aging | Short and Long-Term Benefits of CR
BOWL AND DOILY SPIDER LIFE SPAN
Normal diet
average: 50 days
maximum: 100 days
Caloric restriction
average: 90 days;
maximum: 139 days
GUPPY LIFE SPAN
Normal diet
average: 33 months
maximum: 54 months
Caloric restriction
average: 46 months
maximum: 59 months
PROTOZOAN LIFE SPAN
Normal diet
average: 7 days;
maximum: 14 days
Caloric restriction
average: 13 days
maximum: 25 days
WHITE RAT LIFE SPAN
Normal diet
average: 23 months;
maximum: 33 months
Caloric restriction
average: 33 months
maximum: 47 months
Animal data sourced from San Diego Union-Tribune article

Calorie Restriction Lab Results: Khurram Hashmi

Test Parameter (12 hr fast)
Range
4 months pre-CR: Nov. 1999
9 months into CR: Oct 2000
17 months into CR: July 2001
 23 months into CR: Jan 2002 29 months into CR: July 2002 34 months into CR: Nov 25, 2002 MetaMetrix: 34 months into CR: Nov 25, 2002
Age, yrs   32 33 33 34 34 35 35
Weight, lbs   180 lbs 127 lbs (I lost weight too quickly; please do not follow my bad example!) 120 lbs / 54.43 kg 119.5 lbs / 54.2kg 115.5 lbs / 52.4kg 116.5 116.5
Height, in/cm   72/183 72/183 72/183 72/183 72/183 72/183 72/183
Daily Caloric Intake, kcal   3200?? 1800 - 1900 1950 - 2050 1950 2000 2150-2200 2150-2200
Blood Type   A+ A+ A+ A+ A+ A+ A+
Blood Pressure   110/60 102/60 95/57 95/57 91/57 91/57 91/57
Mean Body Temp, F/C   98.6 ? 97.35 F (average of 6 readings) 97.51 F (average of 10 readings) 97.2/37.2 97.2/37.2 97.2/37.2 97.2/37.2
Mean Heart Rate, cycles/min   ~ 73 - 75 65 (mostly due to increase in exercise) 63.9 (mostly due to increase in exercise) 63 61 61 61
Cholesterol (total) mg/dl 150-200 217 154 149 181 189 158  
LDL Chol, mg/dl <100 best 160 93 81 101 104 88  
VLDL Chol, mg/dl 0 - 40   8 4 8 12 4  
HDL Chol, mg/dl >59 42 53 64 72 73 66  
Ratio Chol/HDL 2.3 5.2 2.9 2.3 2.5 2.6 2.4  
Ratio LDL/HDL   3.08 1.8 1.27 1.4 1.424    
Triglyceride, mg/dl 27-150 75 39 22 39 59 18  
CBC-WBC, x10E9/L 3.7-10.8 11.3 9.1 5.3 5.7 4.6 5.3  
CBC-RBC, x10E9/L 4.00-5.50 4.73 4.37 3.84 3.87 3.66 3.76  
Hemoglobin, g/dL 13.1-17.3 14.8 14.1 12.8 13.5 13.0 13.4  
Hematocrit, % 39-49 46.0 41.4 37.7 39.0 37.9 38.4  
MCV, fL 80-99 97.1 94.7 98 101 104 102  
MCH, pg 27-34 31.2 32.2 33.4 34.8 35.5 35.6  
MCHC, g/dL 32-37 32.1 34.0 34.0 34.5 34.3 34.8  
RDW, % 11.4-14.3 12.0 12.6 12.2 11.5 12.3 13.3  
Platelet Count, x10E9/L 132-356 278 239 189 205 210 221  
MPV, fL 7-12 8.9 ? 8.7 8.9 9.0 8.6  
Glucose, fasting 12 hrs 65-110 75 75 84 81 72 81  
Cortisol, PM < 10 ug/dL Not Tested Not Tested Not Tested 4.3 13.3 8.8  
Insulin 1.90-23.00 ? <1 0.76 0.76 1.09 1.63 1.0

2 hr glucose tolerance test: fasting, mg/dl

   Not Tested 77          
1/2 hr glucose, mg/dl
   Not Tested 126          
1 hr glucose, mg/dl
   Not Tested 142          
2 hr glucose, mg/dl
   Not Tested 120          
Urine glucose: fasting
  Not Tested Negative          
Urine glucose: 1/2 hr
   Not Tested Negative          
Urine glucose: 1 hr
   Not Tested Negative          
Urine glucose: 2 hr
   Not Tested Negative          
DHEA   Not Tested 5.4          
HgbA1C   Not Tested 5.2       4.6  
Anti Nuclear Antibodies: Tested by IFA on HEP-2 Cells   Not Tested Negative at 1:80          
Creat Clearance: Volume   Not Tested 1850          
Creat Clearance: Collection   Not Tested 7am 27 Oct 2000 - 7am 28 Oct 2000          
Creat Clearance: Serum Creat   Not Tested 0.8          
Creat Clearance Creat, UR   Not Tested 67.3          
Creat Clearance   Not Tested 108 108        
Basic Metabolic/ Renal Panel                
BUN
 5-23 15 22 21 22 19 17  
Creatinine
 0.0-1.4 1.0 0.8 0.8 0.8 0.8 0.7  
Sodium
 134-146 139 136 140 138 140 143  
Potassium
 3.5-5.0 3.8 4.5 3.9 4.2 4.2 3.8  
Chloride
 98-109 99 101 101 100 98 101  
CO2
 21-30 24 30 33 30 32 32  
Calcium
 8.5.10.5 10.0   9.9 9.5 10.2 9.8  
T. Bilirubin
 0.2-1.0 0.9 1.2 1.2 1.0 1.1    
D. Bilirubin
 0.0-0.4 0.2 0.2 0.2        
Alk Phos
 39-117 48 33 32        
Ast-SGOT
 0-41 26 25 26   29 34  
Alt-SGPT
 0.40 31 24 25   21 26  
T. Protein
   8.0 7.3     7.5 7.0  
Albumin
 3.2-5.3 4.8 4.6 4.9        
Iron, ug/dL 65-170 120     79 77 89  
Ferritin, ng/mL 24-336       128 101 92 128
Fibrinogen, mg/dL 175-400             197
c-Reactive Protein <=0.05             <.02
EKG/ECG:   Not Tested   Not Tested        
Vent Rate
   Not Tested 65 bpm Not Tested        
P Duration
   Not Tested 102 ms Not Tested        
QRS Duration
   Not Tested 78 ms Not Tested        
PR Interval
   Not Tested 146 ms Not Tested        
QT Interval
   Not Tested 378 ms Not Tested        
QTc Interval
   Not Tested 385 ms Not Tested        
QT Dispersion
   Not Tested 14 ms Not Tested        
P-R-T AXIS
   Not Tested 71 - 81 - 67 Not Tested        
Free T4, ng/dL 0.71-1.185     1.02        
TSH, uIU/mL 0.4-4.2     1.48 0.92      
Urinalysis                
PH
 5.0-9.0     6.5        
Urobilinogen
 <1.1     0.2        
Testosterone 200-810             226
Free Testosterone 10.0-30.0 PG/ML     2.7 6.7 5.0 3.9  
Sex Hormone Binding Globulin, mol/L               42
Free Androgen Index (calc.)               19
IGF-I (Somatomedin C), ng/mL 100-390           173  

MetaMetrix ION (Individual Optimal Nutrition) Test

Category/Sub-category/Test parameter Range Results Date: 2002-11-25
Amino Acids - 20 Plasma    
EAAs
    
Arginine 70-160 umol/L 40
Histidine    
Isoleucine    
Leucine    
Lysine    
Methonine    
Phenylalanine    
Threonine    
Tryptophan    
Valine    
EAA Derivatives: Neuroendocrine Metabolism
    
Glycine    
Serine    
Taurine    
Tyrosine    
EAA Derivatives: Ammonia/Energy Metabolsim
    
Asparagine    
Aspartic Acid    
Citruline    
Glutamic Acid    
Glutamine    
Ornithine    
Element- Erythocyte (RBC) ppm, packed cells  
Essential Elements
    
Calcium    
Chromium    
Copper    
Magnesium    
Molybdenum 0.008-0.030 0.005
Potassium    
Selenium    
Vanadium    
Zinc    
Toxic Element
    
Aluminium    
Cadmium    
Lead    
Mercury <=0.005 0.006
CoQ10 Plus Vitamin Panel - Serum    
CoQ10
    
Vitamin E 12.0-50.0 10.2
Vitamin A    
B-Carotene    
Fatty Acids - Plasma uM  
PUFA Omega 3
    
18:3n3 15-30 44
20:5n3 20-80 130
22:5n3 15-35 26
22:6n3 70-150 85
PUFA Omega 6
    
18:2n6 Linoleic 1200-2500 1155
18:3n6 Gamma Linolenic 10-26 6
20:2n6 Eicosadienoic 6-16 9
20:3n6 Dihomogamma Linolenic 45-115 21
20:4n6 Arachidonic 300-700 239
22:2n6 Docosadienoic <=7.0 2.8
22:4n6 Docosatetraenoic 8.0-17.0 7.1
PUFA Omega 9
    
20:3n9    
Monounsaturated
    
18:1n7    
14:1n5    
16:1n7    
18:1n9    
20:1n9    
22:1n9    
24:1n9    
Saturated
    
10:0    
12:0    
14:0    
16:0    
18:0    
20:0    
22:0    
24:0    
26:0    
Odd Chain
    
15:0    
17:0    
19:0    
21:0    
23:0    
Trans
    
16:1n7    
C:18 Trans    
Ratios, uM
 uM  
LA/DGLA 12-35 55
EPA/DGLA 0.2-1.00 6.2
AA/EPA 5-35 2
Triene/Tetraene <=0.012 0.016
Lipid Peroxide nmol/mL  
Lipid Peroxides <=1.0 2.7
Organix - Urine    
Fatty Acid Metabolism
    
Adipate    
Suberate    
Ethylmalonate    
Carbohydrate Metabolism
    
Pyruvate    
Lactate    
a-Hydroxybutyrate    
B-Hydroxybutyrate    
Energy Production (Citric Acid Cycle)
    
Citrate    
Cis-Aconitate    
Isocitrate    
a-Ketoglutarate    
Succinate    
Fumarate    
Malate    
Hydroxymethylglutarate    
B-Complex Vitamin Markers
    
a-Ketoisovalerate    
a-Ketoisocaproate    
a-Keto-B-Methylvalerate    
(to be added)    
Neurotransmitter Metabolism Markers
    
(to be added)    
Detoxication Indicators
    
(to be added)    
Intestinal Dysbiosis- Bacterial
    
(to be added)    
Intestinal Dysbiosis- Clostridial
    
(to be added)    
Intestinal Dysbiosis- Yeast/Fungal
    
(to be added)    
Homocysteine - Plasma nmol/mL  
Homocysteine <=8 9

The first tests (1999) were done 3-4 months before I "officially" started CR. Nevertheless, I had been controlling my diet by lowering the number of calories consumed; and somewhat controling nutrition quality. 1999 tests were done by Quest Diagnostics Inc, Auburn Hills, Michigan USA. 2000 tests were performed by Pathology Laboratories. 2001 and 2002 tests were performed at Promedica Labs, Toledo and Univ. of Michigan Labs. MetaMetrix tests done by local lab but sent same-day express to MetaMetrix Labs, Norcorss, GA, USA. This is not a complete list by any means. More data to be added later....

Last Update: 2003-01-26

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