Cellular Aging and Cell Death
by: Nikki J. Holbrook (Editor), George R. Martin (Editor), Richard A. Lockshin (Editor)
Topics include: chromosome healing, death commitment point, elegans cell death gene, pathological cell death, elegans cell survival gene, other survival factors, oxidative damage potential, older neurons, human cellular senescence, senescence arrest, escape from senescence, touch receptor neurons, cellular longevity, senescent human fibroblasts, following heat stress, senescent cells, cell corpses, inhibit cell death, cell death genes, undergo cell death, escape from crisis, heat shock protein expression, oncogenic alterations, cell death program, telomere loss
First Sentence:
Species with short life spans have been the primary targets for studies into the genetic basis of the aging process(es).National Institutes of Health, Baltimore, Maryland. Research on the process of cellular aging and apoptosis, or programmed cell death, with implications for development, aging, and disease. For researchers. 48 contributors, 40 U.S. DNLM: Cell Aging.
The publisher, John Wiley & Sons
Experts from top laboratories provide an authorative overview of current knowledge in understanding the basic mechanisms responsible for aging and the control of cellular proliferation and programmed cell death. Emphasizes the interrelationship between the molecular, cellular and physiological aspects of senescence.
Based on research gleaned from:
Biol Chem, Mol Cell Biol, Cancer Res, Exp Cell Res, Genes Dev, Dev Biol, Clin Invest, Biochem Biophys Res Commun, Mech Ageing Dev, Exp Gerontol, National Institute, Nucleic Acids Res, Mutat Res, Cell Physiol, Cold Spring Harbor, Academic Press, Anat Embryol, Ann Neurol, Arch Biochem Biophys, Cell Sci, Nature Genet, Annu Rev Neurosci, Immunol Today, Physiol Rev, Hum Genet
Reviews:
Human body is made of cells, its aging is important. Cell of the body must have the proper environment. Developmental changes (age changes) can be explained better at the cellular level. Errant condition and failure to correct lead to cell injury. The greater the number of cells injured the more likely system malfunction would occur.